Table 1.

Half-maximal inhibitory concentration (IC₅₀) values for the antiproliferative effects of 5-fluorouracil, sorafenib, and celecoxib on the growth of multicellular spheroids and monolayer cells in vitro

IC50	Multicellular spheroids	Monolayer cells	P-value
5-fluorouracil	20.25±4.93 × 10−3 g/L	10.28±3.18 × 10−3 g/L	<0.05
Sorafenib	7.00±2.32 μM	4.08±1.54 μM	<0.05
Celecoxib	60.59±15.88 μM	31.02±12.39 μM	<0.05

Note: Each test was repeated in triplicate.