Table 1. Differentially expressed genes in Mtb treated with db-cAMP relative to butyric acid treated bacteria.
Gene productb | Locus | Change in expression (fold) | SD (fold) | P value |
CHP | Rv0146 | –5.9 | 0.0 | 0.01 |
CHP | Rv0264c | 2.9 | 1.6 | 0.02 |
DnaK | Rv0350 | 3.7 | 0.6 | 0.02 |
GrpE | Rv0351 | 2.9 | 0.9 | 0.05 |
DnaJ | Rv0352 | 3.2 | 0.7 | 0.03 |
MmpS5 | Rv0677c | –2.1 | 0.2 | 0.00 |
CHP | Rv1057 | 2.3 | 0.2 | 0.04 |
CHP | Rv1330c | 2.0 | 1.0 | 0.03 |
CMP | Rv2025c | 9.8 | 4.4 | 0.02 |
FadD9 | Rv2590 | –5.1 | 0.1 | 0.04 |
HupB | Rv2986c | –2.0 | 0.0 | 0.02 |
TRP | Rv3830c | –8.5 | 0.0 | 0.03 |
Expression of 3924 genes of Mtb was compared between the cells treated with db-cAMP and butyric acid. An average of data from three independent experiments (p≤ 0.05) is included in the table. Genes that exhibit ≥2-fold difference in expression levels by whole-genome microarray are shown. SD: standard deviation. bCHP, CMP and TRP denote conserved hypothetical protein, conserved membrane protein and transcription regulatory protein, respectively.