Table 1. General characteristics of subjects with hemorrhagic transformation at initial MRI and all imaging.
| Patients with Hemorrhagic infarction | All patients with HT | |||||
| HI-1 (N = 75) | HI-2 (N = 75) | P | HI (N = 150) | PH (N = 72) | p | |
| Age (mean±SD) | 71.17±10.89 | 71.13±12.40 | 0.276 | 71.15±11.63 | 69.01±10.90 | 0.192 |
| Male (n, %) | 50 (66.7) | 49 (65.3) | >0.999 | 99(66.0) | 44(61.1) | 0.549 |
| Risk factors (n, %) | ||||||
| HTN | 47 (62.7) | 53 (70.7) | 0.387 | 100 (66.7) | 52 (72.2) | 0.443 |
| DM | 28 (37.3) | 17 (22.7) | 0.074 | 45 (30.0) | 19 (26.4) | 0.637 |
| Smoking | 24 (32.0) | 17 (22.7) | 0.272 | 41(27.3) | 20 (27.8) | >0.999 |
| Dyslipidemia | 20 (26.7) | 19 (25.3) | >0.999 | 39 (26.0) | 11 (15.3) | 0.087 |
| Previous stroke | 10 (13.3) | 11 (14.7) | >0.999 | 21(14.0) | 9 (12.5) | 0.836 |
| Atrial fibrillation | 46 (61.3) | 47 (62.7) | >0.999 | 93(62.0) | 41 (56.9) | 0.558 |
| Visit time after onset, min (mean±SD), | 560.68±792.6 | 425.00±727.24 | 0.983 | 492.84±761.12 | 392.25±913.00 | 0.389 |
| Baseline NIHSS (med, IQR) | 9.0 (11.0) | 11.0 (9.0) | 0.089 | 11.0 (9.0) | 13.0 (6.75) | 0.002 |
| Thrombolysis (n, %) | 0.827 | 0.006 | ||||
| IV only | 17 (22.7) | 21 (28.0) | 38 (25.3) | 28 (38.9) | ||
| IA or IV+IA | 12 (16.0) | 11 (14.7) | 23 (15.3) | 17 (23.6) | ||
| First anti-thrombotics (before HT) (n, %) | N = 68 | N = 65 | 0.167 | <0.001 | ||
| None | 8 (11.8) | 17 (26.2) | 65 (43.3) | 61 (84.7) | ||
| Anti-platelet | 241 (60.3) | 31 (47.7) | 52 (34.7) | 9 (14.8) | ||
| Anti-coagulation | 119 (227.9) | 17 (26.2) | 33 (22.0) | 2 (2.8) | ||
| Anti-thrombotics after HT (n, %) | 0.001 | <0.001 | ||||
| None | 15 (20.0) | 35 (46.7) | 50 (32.3) | 68 (94.4) | ||
| Anti-platelet | 41 (54.7) | 31 (41.2) | 72 (48.0) | 4 (5.6) | ||
| Anti-coagulation | 19 (25.3) | 9 (12.0) | 28 (18.7) | 0 | ||
| Neurological deterioration after HT (n, %) | 2 (2.7) | 4 (5.3) | 0.681 | 6 (4.0) | 10 (13.9) | 0.012 |
| Aggravation of HT at FU imaging (n, %) | 5 (6.7) | 11 (14.7) | 0.185 | 16 (10.7) | 14 (19.4) | 0.093 |
| Composite events within 1month (n, %) | 1 (1.3) | 4 (5.3) | 0.367 | 5 (3.3) | 7 (10.8)* | 0..047 |
HTN, hypertension; DM, diabetes mellitus; NIHSS, National Institutes of Health Stroke Scale; IV, intravenous; IA, intra-arterial; HT, hemorrhagic transformation; END, early neurological deterioration; FU, follow-up.
*N = 65 (due to loss of follow-up).