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. 2014 Feb 28;9(2):e90040. doi: 10.1371/journal.pone.0090040

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© 2014 Kambara et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) Ai E/I ratio from the 3^rd to the 6^th generation compared according to the spirometric COPD stage. There were no significant differences in the Ai E/I ratio at any of the 3^rd to 6^th generations of the airways when compared according to the spirometric COPD stage. Rather, Ai E/I ratio of more severe COPD subjects tended to be higher comparing with mild COPD subjects. (b) Ai E/I ratio corrected by lung volume change from inspiration to expiration (LV E/I ratio) from the 3rd to the 6th generation compared according to the spirometric COPD stage. Ai E/I ratio corrected by lung volume change from inspiration to expiration (LV E/I ratio) was significantly different among the groups according to COPD severity.