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. 2014 Feb 28;9(2):e90024. doi: 10.1371/journal.pone.0090024

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© 2014 Schlichter et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Sequence alignments of C-termini for the EAG family of K⁺ channels show each immuno-receptor tyrosine inhibitory motif (ITIM) in bold, with its potentially phosphorylated tyrosine residue in parentheses beside the channel name. Also shown for hERG/Kv11.1/KCHN2 is the sequence of the 15 amino acid peptide made for use in pull-down assays or deleted in the ΔITIM mutant channel (line above the sequence).