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. 2014 Feb 28;9(2):e90024. doi: 10.1371/journal.pone.0090024

Figure 7. SHP-1 tyrosine phosphatase regulates the hERG current.

Figure 7

Currents were compared between cells recorded with pipette solutions containing saline (control), or 100 µg/mL of active recombinant wild-type SHP-1 (A, B), or a 3∶1 mixture of the inactive substrate-trapping SHP-1 mutant (SHP-1 C453S; 150 µg/mL) and wild-type SHP-1 (50 µg/mL) (C, D). The same voltage protocols and normalization procedures were used as in Figure 3. For each panel, representative current traces from two different cells are shown, and the lower graphs summarize the time-dependent changes in peak currents. Significant differences between control cells and cells containing SHP-1 proteins are indicated: *p<0.05; **p<0.01.