Table 2.
Final Regression Models for Changes in Carotid Intima-Media Thickness
A. Common Carotid Artery
| ||||||
---|---|---|---|---|---|---|
Baseline to Week 96 | Week 96 to Week 144 | |||||
| ||||||
Beta | SE (Beta) | P | Beta | SE (Beta) | P | |
Sex | 0.124 | 0.060 | 0.05 | −0.098 | 0.031 | <0.01 |
Race | 0.100 | 0.064 | 0.13 | −0.064 | 0.033 | 0.06 |
WC | 0.003 | 0.003 | 0.35 | |||
LDL-C | <−0.001 | <0.001 | 0.39 | 0.001 | <0.001 | 0.05 |
HDL-C TG |
0.001 | <0.001 | 0.16 | |||
HOMA-IR | −0.032 | 0.015 | 0.04 | 0.011 | 0.009 | 0.23 |
Change in BMI | 0.028 | 0.016 | 0.10 | |||
Change in TG | <0.001 | <0.001 | 0.99 | |||
PI duration at endpoint | −0.002 | <0.001 | 0.03 | |||
|
||||||
R2 = 0.61 | R2 = 0.49 |
B. Internal Carotid Artery
| ||||||
---|---|---|---|---|---|---|
Baseline to Week 96 | Week 96 to Week 144 | |||||
| ||||||
Beta | SE (Beta) | P | Beta | SE (Beta) | P | |
| ||||||
Age | 0.020 | 0.011 | 0.08 | |||
Race | 0.089 | 0.125 | 0.48 | |||
WC | 0.001 | 0.010 | 0.91 | |||
HDL-C | 0.001 | 0.003 | 0.63 | |||
Change in TG | <−0.001 | <0.001 | 0.46 | |||
HIV duration at baseline | 0.001 | 0.001 | 0.24 | |||
ART duration at endpoint | −0.003 | 0.001 | 0.06 | <0.001 | 0.001 | 0.41 |
PI duration at endpoint | −0.002 | 0.003 | 0.54 | |||
|
||||||
R2 = 0.44 | R2 = 0.27 |
LDL, low-density lipoprotein; HDL, high-density lipoprotein; TG, triglycerides; HOMA-IR, homeostasis model assessment of insulin resistance; BMI, body mass index; PI, protease inhibitor; WC, waist circumference; ART, antiretroviral therapy