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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Hepatology. 2014 Apr 1;59(5):1761–1771. doi: 10.1002/hep.26714

Figure 6. Hepatic CES1 is regulated by FXR.

Figure 6

(A–C) C57BL/6 mice were gavaged with vehicle (0.5% CMC (carboxymethyl cellulose)) or GW4064 (30 mg/kg, twice a day) for 7 days (n=8 mice per group). Hepatic TG and TC levels were determined (A). Hepatic mRNA levels were quantified by qRT-PCR (B) and hepatic protein levels were determined by Western blot assays (C). (D) C57BL/6 mice were gavaged with either 0.5% CMC (vehicle) or INT-747 (OCA, 30 mg/kg/d) for 7 days (n=5 mice per group). Hepatic mRNA levels were determined. Cyp7a1 and Cyp8b1 serve as positive controls. (E) C57BL/6 mice were fed a chow diet or 0.5% cholic acid (CA) for 7 days. Hepatic mRNA levels were quantified. (F) Hepatic mRNA levels were quantified by qRT-PCR in wild-type or Fxr−/− mice (n=8 mice per group).