Figure 4. The effect of Cu^II(atsm) on Cu levels and neurite elongation.

(A) ICP-MS results showed that 18 hr exposure to 50 nM Cu^II(atsm) increased cellular Cu content slightly while 500 nM had no effect on cellular Cu levels (n = 6/treatment). (B) The effect of Cu^II(atsm) (500 nM, 18 hr) on neurite elongation (assessed as % neurites 2x or more than cell body width). Cu^II(atsm) at 500 nM concentration induced a significant increase in neurite elongation similar to that induced by 50 nM Cu^II(gtsm) (n = 4/treatment). Values are mean ± SEM. *p<0.05, **p<0.01.