Figure 5.

Phylogenetic classification of C. forskohlii diterpene synthases with known class II (A) and class I (B) sequences. The phylograms are rooted with the bifunctional ent-copalyl diphosphate synthase/ent-kaurene synthase from the moss P. patens. Asterisks indicate nodes supported by greater than 80% bootstrap confidence, and the scale bar indicates 0.1 amino acid changes. The numbers indicated at each enzyme refer to their respective enzymatic products, the structures of which are given on the right. Species and GenBank accession are given in Supplemental Table S2.