Table 3.
Sonographic and clinical factors for IVIG resistance in children with Kawasaki disease
| Variables |
IVIG response |
IVIG resistance |
P value | OR (95% CI) |
|---|---|---|---|---|
| (n = 47) | (n = 17) | |||
|
Sonographic factors | ||||
| Abnormal GB |
15 (31.9%) |
8 (47.1%) |
0.377 |
1.896 (0.611 ~ 5.887) |
| GB distension |
10 (21.3%) |
8 (47.1%) |
0.060 |
3.289 (1.010 ~ 10.715) |
| GB wall thickness |
5 (10.6%) |
0 (0%) |
0.313 |
0.894 (0.810 ~ 0.986) |
| GB sludge |
0 (0%) |
2 (11.8%) |
0.067 |
1.133 (0.953 ~ 1.348) |
| Abnormal liver |
11 (23.9%) |
2 (11.8%) |
0.485 |
0.424 (0.084 ~ 2.151) |
|
Clinical factors | ||||
| Hyperbilirubinemia |
26 (55.3%) |
10 (58.8%) |
1.000 |
1.154 (0.375 ~ 3.551) |
| Typical Kawasaki disease |
28(59.6%) |
11(64.7%) |
0.778 |
0.207(0.014 ~ 3.137) |
| Fever ≥ 5 days |
43(91.5%) |
16(94.1%) |
1.000 |
0.339(0.012 ~ 9.676) |
| Dysmorphous skin rash |
41(87.2%) |
15(88.2%) |
1.000 |
0.647(0.082 ~ 5.093) |
| Oral mucosal change |
37(78.7%) |
12(70.6%) |
0.517 |
0.262(0.041 ~ 1.659) |
| Conjunctivitis |
41(87.2%) |
13(76.5%) |
0.435 |
0.199(0.023 ~ 1.732) |
| Cervical lymphadenopathy |
34(72.3%) |
11(64.7%) |
0.552 |
0.656(0.149 ~ 2.888) |
| Peripheral extremity change | 21(44.7%) | 13(76.5%) | 0.045* | 3.579(0.846 ~ 15.136) |
*p < 0.05.
CI, confidence interval; GB, gallbladder; IVIG, intravenous immunoglobulin; OR, odds ratio.