Table 4. Description of the top ten canonical pathways significantly modulated in bovine backfat tissue when comparing fetal stage with adult stage.

Ingenuity canonical pathways	Genes
PPARα/RXRα Activation	ACADL, CD36, ABCA1, ERK1/2, HDL-cholesterol, LDL, N-cor, Pka, Proinsulin, Rxr
FXR/RXR Activation	HDL-cholesterol, PPARG, SLC10A1, SREBF1, HNF4A, LDL, Nr1h, PEPCK, Proinsulin, Rxr
LXR/RXR Activation	LDLR, SREBF1, CD36, ACACA, ABCA1, HDL-cholesterol, LDL, N-cor, Nr1h, Rxr
Hepatic Cholestasis	HDL-cholesterol, SLC10A1, SREBF1, HNF4A, ESR1, HSD3B7, N-cor, Pka, Proinsulin, Rxr
LPS/IL-1 Mediated Inhibition of RXR Function	SLC10A1, FABP5, SREBF1, ALAS1, ACSL1, ABCA1, HDL-cholesterol, LDL, Nr1h, Rxr
RAR Activation	RDH10, PIK3R1, BMP2, ERK1/2, HDL-cholesterol, LDL, N-cor, Rxr, SRC
TR/RAR Activation	LDLR, HDL-cholesterol, SREBF1, N-cor, PEPCK, ACACA, Rxr, PCK1
AMPK Signaling	PIK3R1, LIPE, ACACA, PPP2R5A, ERK1/2, Pka, SRC, Proinsulin
ERK/MAPK Signaling	ERK1/2, ESR1, Pka, PPARG, PPP2R5A, SRC
PPAR Signaling	ERK1/2, N-cor, Nr1h, PPARG, Proinsulin, Rxr

Note: Statistical significance of pathway modulation was calculated via a right-tailed Fisher's Exact test in Ingenuity Pathway analysis and represented as –log (P value): -log values exceeding 1.30 were significant FDR<0.05.