Table 3. Frequency distribution of DR4 haplotypes in GBC patients and HC.

Haplotypes	Frequency		p- value	OR (95%CI)
	HC 246 (%)	GBC 400 (%)
Crs20575Ars20576Grs6557634	0.5917	0.4316	---	Reference
Crs20575Ars20576Ars6557634	0.119	0.2095	<0.0001a	2.76 (1.71 – 4.47)
Grs20575Ars20576Grs6557634	0.0947	0.1427	0.0084b	2.09 (1.21 – 3.62)
Grs20575Ars20576Ars6557634	0.1154	0.0737	0.62	0.86 (0.47 – 1.57)
Grs20575Crs20576Grs6557634	0.0306	0.0719	0.022c	2.80 (1.16–6.76)
Grs20575Crs20576Ars6557634	0.0337	0.028	0.23	1.75 (0.71–4.32)
Crs20575Crs20576Grs6557634	0.0127	0.0288	0.31	1.83 (0.57–5.92)
Global haplotype association p-value: 0.00038d

HC - Healthy control, GBC - Gallbladder cancer, OR - Odds Ratio, CI - Confidence Interval.

Significant Values are given in bold, FDR pcorr = 0.0005^a, 0.0244^b, 0.0335^c, 0.0015^d.