. 2014 Feb 28;9(2):e90264. doi: 10.1371/journal.pone.0090264

Table 4. Haplotype Analysis of DR4 gene in GBC and HC after gender stratification.

Haplotypes	Haplotype Analysis of DR4 in male				Haplotype Analysis of DR4 in females
	Frequency				Frequency
	HC (83)	GBC (122)	p- value	OR (95%CI)	HC (163)	GBC (278)	p- value	OR (95%CI)
C_rs20575A_rs20576G_rs6557634	0.5826	0.4181	---	Reference	0.6008	0.4366	---	Reference
C_rs20575A_rs20576A_rs6557634	0.1309	0.2351	0.013^a	3.55 (1.32–9.54)	0.1079	0.1984	0.0000^b	2.60 (1.49 –4.52)
G_rs20575A_rs20576G_rs6557634	0.1122	0.1435	0.069	2.44 (0.94–6.34)	0.084	0.1435	0.035^c	2.10 (1.06 – 4.17)
G_rs20575A_rs20576A_rs6557634	0.108	0.0681	0.74	0.81 (0.22–2.90)	0.1215	0.0758	0.066	0.86 (0.43–1.70)
G_rs20575C_rs20576G_rs6557634	0.016	0.0447	0.092	9.10 (0.71–117.02)	0.0392	0.0803	0.073	2.31 (0.93–5.78)
G_rs20575C_rs20576A_rs6557634	0.0349	0.0265	0.34	0.57(0.07–4.89)	0.0314	0.0313	0.12	2.39 (0.80–7.19)
C_rs20575C_rs20576G_rs6557634	0	0.0495	0.61	5.57 (0.17–186.44)	0.0153	0.0231	0.59	1.43 (0.38–5.36)
C_rs20575C_rs20576A_rs6557634	0.0154	0.0145	0.36	4.78 (0.17–136.99)	NA	0.011	0.0000	……
	Global haplotype association p-value = 0.11				Global haplotype association p-value = 0.0092^d

GBC - Gallbladder cancer, HC - Healthy controls, OR - Odds Ratio, CI - Confidence Interval

Significant Values are given in bold, FDR pcorr = 0.0277 ^a, 0 ^b, 0.0430 ^c, 0.0245^d.