Table 4. Haplotype Analysis of DR4 gene in GBC and HC after gender stratification.
| Haplotypes | Haplotype Analysis of DR4 in male | Haplotype Analysis of DR4 in females | ||||||
| Frequency | Frequency | |||||||
| HC (83) | GBC (122) | p- value | OR (95%CI) | HC (163) | GBC (278) | p- value | OR (95%CI) | |
| Crs20575Ars20576Grs6557634 | 0.5826 | 0.4181 | --- | Reference | 0.6008 | 0.4366 | --- | Reference |
| Crs20575Ars20576Ars6557634 | 0.1309 | 0.2351 | 0.013a | 3.55 (1.32–9.54) | 0.1079 | 0.1984 | 0.0000b | 2.60 (1.49 –4.52) |
| Grs20575Ars20576Grs6557634 | 0.1122 | 0.1435 | 0.069 | 2.44 (0.94–6.34) | 0.084 | 0.1435 | 0.035c | 2.10 (1.06 – 4.17) |
| Grs20575Ars20576Ars6557634 | 0.108 | 0.0681 | 0.74 | 0.81 (0.22–2.90) | 0.1215 | 0.0758 | 0.066 | 0.86 (0.43–1.70) |
| Grs20575Crs20576Grs6557634 | 0.016 | 0.0447 | 0.092 | 9.10 (0.71–117.02) | 0.0392 | 0.0803 | 0.073 | 2.31 (0.93–5.78) |
| Grs20575Crs20576Ars6557634 | 0.0349 | 0.0265 | 0.34 | 0.57(0.07–4.89) | 0.0314 | 0.0313 | 0.12 | 2.39 (0.80–7.19) |
| Crs20575Crs20576Grs6557634 | 0 | 0.0495 | 0.61 | 5.57 (0.17–186.44) | 0.0153 | 0.0231 | 0.59 | 1.43 (0.38–5.36) |
| Crs20575Crs20576Ars6557634 | 0.0154 | 0.0145 | 0.36 | 4.78 (0.17–136.99) | NA | 0.011 | 0.0000 | …… |
| Global haplotype association p-value = 0.11 | Global haplotype association p-value = 0.0092d | |||||||
GBC - Gallbladder cancer, HC - Healthy controls, OR - Odds Ratio, CI - Confidence Interval
Significant Values are given in bold, FDR pcorr = 0.0277 a, 0 b, 0.0430 c, 0.0245d.