Table 4. Disability and health-related quality of life features associated with clinically significant symptoms of anxiety and depression in patients with systemic sclerosis.
| All patients n = 381 | Patients with anxiety symptoms | Patients without anxiety symptoms | p-value | Patients with depression symptoms | Patients without depression symptoms | p-value | |
| n = 224 | n = 157 | n = 154 | n = 227 | ||||
| SF-36 | |||||||
| • Physical functioning | 26 (18–50) | 25 (15–50) | 26 (20–55) | 0.011 | 25 (16–50) | 27(21–55) | 0.015 |
| • Physical role | 5 (4–8) | 4 (0–8) | 6 (4–25) | 0.003 | 4 (4–8) | 7 (4–25) | <0.001* |
| • Bodily pain | 5 (3–41) | 2 (5–34) | 5 (3.41) | <0.001* | 5 (3–41) | 6 (4–41) | 0.053 |
| • General health perception | 12 (9–35) | 13 (9–30) | 11 (9–44) | 0.005 | 11 (9–30) | 12 (9–49) | 0.773 |
| • Vitality | 10 (6–35) | 8 (5–31) | 10 (6–40) | <0.001* | 8 (7–35) | 11 (7–45) | 0.063 |
| • Social functioning | 5 (3–50) | 5 (3–63) | 5 (3–50) | <0.001* | 4 (3–50) | 5 (4–75) | 0.004 |
| • Emotional role | 5 (3–33) | 3 (0–5) | 6 (3–67) | <0.001* | 3 (2–6) | 6 (5–100) | <0.001* |
| • Mental health | 17 (13–56) | 15 (10–44) | 18 (14–60) | <0.001* | 15 (11–44) | 18 (15–65) | <0.001* |
| • PCS | 35 (29–42) | 33 (27–39) | 36 (29–44) | <0.001* | 33 (28–39) | 38 (30–45) | 0.002 |
| • MCS | 34 (25–41) | 28 (21–34) | 37 (29–38) | <0.001* | 29 (23–37) | 39 (33–49) | <0.001* |
| HAQ (0–3) | 1 (0.5–1.6) | 1.1 (0.5–2) | 0.9 (0.4–1.5) | 0.009 | 1.1 (0.5–1.8) | 0.8 (0.4–1.5) | <0.001* |
| MACTAR (0–30) | 19.5 (15–24) | 18.5 (13–24) | 18.5 (15–25) | 0.192 | 20 (15–24) | 18 (13–24) | <0.001* |
| CHFS (0–90) | 14 (4–30) | 20 (7–42) | 12 (3–27) | <0.001* | 19 (6–35) | 10 (2–25) | <0.001* |
| MHISS (0–48) | 19.5 (9–27) | 18 (18–28) | 15 (6–24.5) | <0.001* | 23 (15–27) | 11 (4–25) | <0.001* |
| Aesthetic impairment (0–10) | 5 (3–7) | 5 (4–7) | 4 (2–6) | 0.068 | 5 (4–7) | 4 (2–6) | <0.001* |
Values are given in median (interquartile range).
*After Bonferroni correction for multiple comparisons, a p-value less than 0.001 was considered statistically significant.
CHFS: Cochin Hand Function Scale; HAQ: Health Assessment Questionnaire; MACTAR: McMaster-Toronto Arthritis Patient Preference Disability Questionnaire; MCS: Mental Component Score; MHISS: Mouth Handicap In Systemic Sclerosis Scale; n: number; PCS: Physical Component Score; SF-36: Medical Outcomes Study 36-Item Short Form Health Survey.