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(A) Composition of PRC2 showing the complex of SUZ12, EZH2 (containing the SET domain), EED and the association of PHF1. (B) Design template of a histone fragment bound to vSET (grey), PDB code: 2G46. The first nine residues of the histone fragment, which make no contacts with vSET, are colored yellow, while the 21 residues that do make contacts are colored red. The SAH cofactor is colored blue.
