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. 2014 Feb 28;9(2):e90095. doi: 10.1371/journal.pone.0090095

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© 2014 Smadbeck et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Quantitative proteomics distinguish newly generated “heavy” histone methylation at H3K27 from old, “light” methylation. MS monitoring of new H3K27me3 from the in nucleo reaction with (A) SAM only, (B) SAM plus the scrambled control peptide added, and (C) SAM plus SQ037 inhibitor peptide added. Relative abundance levels across all conditions for (D) H3K27me2, (E) H3K27me3 and (F) H3K9me3 are shown. Statistical significance between abundance levels is indicated, *P<0.002 and **P<0.0001. Three biological replicates were used. Note that the specified 12 Da shift is nominal, exact value is 12.062 Da.