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Role of TRAF6 in Ig production. (A–E) Sera collected from TRAF6+/+ mCD40LMP1-negative (n = 7), TRAF6−/− mCD40LMP1-negative (n = 12), TRAF6+/+ mCD40LMP1 Tg (n = 15) and TRAF6−/− mCD40LMP1 Tg (n = 13) mice were tested for levels of IgM (A), IgG1 (B), IgG2b (C), IgG3 (D) and IgA (E). *Statistical difference between TRAF6+/+ and TRAF6−/− mCD40LMP1 Tg mice as determined by the Student’s unpaired t-test, P < 0.05.
