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Effect of intra-PSC microinjections of normal saline (Ns), thioperamide (THI) alone and before histamine (HIS) on the formalin-induced pain. Data are presented as mean ± SEM (n = 6). * P< 0.05 denotes significant difference vs other groups. † P<0.05 denotes significant difference vs thioperamide (1 µg) and histamine (0.25 µg). ‡ P<0.05 denotes significant difference vs thioperamide (4 µg) and histamine (1 µg). (one-way ANOVA and Duncan's test)
