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Effect of intra-PSC microinjections of normal saline (Ns), naloxone (NAL) alone and before histamine (HIS), and thioperamide (THI) on the formalin-induced pain. Data are presented as mean ± SEM (n = 6). * P<0.05 denotes significant difference vs other groups. † P<0.05 denotes significant difference vs histamine (2 µg). ‡ P<0.05 denotes significant difference vs thioperamide (4 µg). (one-way ANOVA and Duncan's test)
