Table 1.
Demographical characteristics of the study population
| Variable | Overall | HBsAg positive | HBsAg negative | p |
|---|---|---|---|---|
| No. of patients |
498 |
38 |
460 |
- |
| Age - Mean [±SD] |
61,00 [±14,05] |
55,42 [±13,62] |
57,32 [±14,95] |
0,45 |
| Sex – M/F |
M: 54,40% - |
M: 57,89% |
M: 47,83% |
0,23 |
| F: 45,40% |
F: 42,11% |
F: 52,17% |
||
| No. of patients HBsAb + |
90 [18,07%] |
0 |
90 [19,56%] |
0,003 |
| No. of patients HBcAb +/ HBsAg - |
134 [26,90%] |
0 |
96 [20,86%] |
0,002 |
| No. of patients HBcAb - / HBsAg - |
274 [55,03%] |
0 |
274 [59,56%] |
|
| Lymphoma type |
Indolent: 47,3% - |
Indolent: 33,35% - |
Indolent: 44,34% - |
0,22 |
| |
Aggressive: 52,7% |
Aggressive: 66,65% |
Aggressive: 55,66% |
0,22 |
| Rituximab therapy |
Yes: 60,30% - |
Yes: 18 [47,37%] |
Yes 262 [56,95%] |
0,25 |
| No: 39,70% |
No: 20 [52,63%] |
No: 198 [43,04%] |
||
| HBV reactivation |
10 [2,01%] |
0 |
10 [2,17%] |
0,22 |
| NUC profilaxys/rescue therapy |
38/10 |
38/0 |
0/10 |
<0,0001 |
| “Per year Incidence of reactivation” [mean ± SD] |
1,71% |
0 |
2,04% |
<0,0001 |
| ±2,43% |
±2,97 |
|||
| Liver related decompensations/hospitalizations/deaths | 0% | 0% | 0% | - |
In the first column overall patients characteristics: HBV reactivation occurred in 2,01% of cases. In the second and third column demographical characteristics of HBsAg positive and negative patients, respectively. HBV reactivation occurred in HBsAg negative patients only, due to the NUC profilaxys performed in HBsAg positive patients [see Methods]. (Chi-square, Pearson corrected calculations for all variables, Age: student t-test).