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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Neurosci. 2013 Jun 30;16(8):1094–1100. doi: 10.1038/nn.3445

Figure 5.

Figure 5

NAcore neurons from alcohol-drinking rats showed hyperpolarization-active NMDARs under mPFC and INS but not BLA inputs to the NAcore. (a,b) AP5 (50 μM) significantly reduced mPFC-ChR2-evoked EPSCs at a −70 mV membrane potential in alcohol-drinking but not control naive rats. (c) AP5-sensitive NMDAR currents were apparent in INS-ChR2-evoked EPSCs at −70 mV from alcohol-drinking but not control rats. (d,e) AP5 had no effect on EPSCs evoked at −70 mV by (d) ChR2 stimulation of BLA-NAcore terminals or (e) electrical field stimulation of glutamatergic terminals within the NAcore. *P < 0.05. Error bars indicate s.e.m.