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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Immunotherapy. 2013 Dec;5(12):1357–1366. doi: 10.2217/imt.13.130

Figure 1. Potential interactions that influence the divergent control of IL-18RAP single nucleotide polymorphism in the pathogenesis of Crohn’s disease and Type 1 diabetes mellitus.

Figure 1

The IL-18RAP rs917997 A/A genotype confers risk for CD and protection against T1D, and vice versa is true for the G/G genotype. The overall risk of developing CD or T1D could be determined by the IL-18RAP rs917997 genotype, modulation of the IL-18 signaling pathway, specific changes in gut microbiota, EV (Norovirus for CD and Coxsackie B4 for T1D) infection of the gut mucosa and/or cell-specific dysfunction of UPR signaling. CD: Crohn’s disease; EV: Enterovirus; IEC: Intestinal epithelial cell; T1D: Type 1 diabetes mellitus; UPR: Unfolded protein response.