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. Author manuscript; available in PMC: 2014 Dec 12.
Published in final edited form as: Oncogene. 2013 Jul 22;33(24):3161–3171. doi: 10.1038/onc.2013.289

Figure 2. Cell cycle arrest and survival during terminal erythroid maturation requires Fbw7-dependent cyclin E regulation.

Figure 2

(A, B) Cell cycle distributions (A) and apoptotic populations using Annexin V staining (B) were measured in bone marrow erythroid cells gated based on CD44/Ter119/FSC as in Figure 1B. Averaged data from six wild-type and cyclin E knock-in mice are displayed. Error bars indicate standard deviation. ** - p-value<0.05; n.s. – p-value>0.05. (C) Bone marrow reticulocytes were identified based on thiazole orange and Hoechst 33342 staining. Data are shown from two representative wild-type and cyclin ET74A T393A pairs, with significantly reduced numbers of cyclin E knock-in bone marrow reticulocytes (retic).

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