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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Cell Microbiol. 2013 Sep 19;16(1):131–145. doi: 10.1111/cmi.12211

Figure 9. P. gingivalis gingipains induce proMMP9 activation and cell invasion in SAS cells.

Figure 9

(A) SAS cells were incubated with P. gingivalis parent and mutants KDP129 (Δkgp), KDP133 (ΔrgpAΔrgpB), and KDP136 (ΔkgpΔrgpAΔrgpB). Culture supernatant samples were analyzed for proMMP9 activation using gelatin zymography. Enzyme activities are expressed from densitometric analyses with arbitrary units. Data are means ± SD of three independent experiments and were analyzed with a t test. (B) SAS cell invasion through matrigel-coated transwells after 24 hours of incubation with P. gingivalis mutants. Data are shown as the mean ± SD of three independent experiments and were analyzed with a t test.