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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Nat Genet. 2014 Jan 26;46(3):279–286. doi: 10.1038/ng.2878

Figure 3. Phylogenetic distribution of drug resistance and compensatory genotypes.

Figure 3

The phylogeny of 1,000 Russian isolates is depicted on the left; lineages are colored as Figure 2. The first 16 columns depict drug resistance loci. ‘P’ denotes a promoter region. Within the 16S rRNA gene, rrsstr refers to the 530 stem-loop and 915 regions involved in streptomycin resistance49 and rrsinj to downstream regions associated with resistance to the second-line injectables36. Colored bands represent different polymorphisms and include previously identified and novel mutations described in the text. The last three columns show nsSNPs in the RNA polymerase genes, rpoABC, excluding those shown in the RRDR. The genotypes illustrated are provided in full in Supplementary Table 4.