Table 1.
PK Parameters | Ass: SS assumption | AMEMS: Full MEMS | AGOLD: Gold standard |
---|---|---|---|
CL/F (L/h) | 7.2 (4.4) | 6.8 | 6.9 (8.1) |
V/F (L) | 79.2 (8.9) | 102 | 81.1 (6.8) |
ka (h−1) | 2.7 (26.8) | 5.6 | 3.2 (42.1) |
MTT (h) | 1.3 (11.2) | 1.5 | 1.35 (11) |
NN | 17.3 (46.7) | 8 | 11.5 (26.4) |
BSV (CL/F) * | 47.4 (28.7) | 44.3 | 40.2 (32.7) |
WSV (CL/F) * | 26.5 (16.9) | <1 | <1 |
BSV (V/F) * | 30.0 (43.2) | 61.4 | 30.1 (28.5) |
BSV (ka) * | 73.5 (47.2) | 120 | 78.4 (73.2) |
BSV (MTT) * | 47.4 (28.7) | 40.1 | 45.2 (31.8) |
RV (week 4) * | 18.7 (16.9) | 27.7 | 19.4 (15.5) |
RV (> week 4) * | 38.0 (33.1) | 47.4 | 43.4 (10.6) |
Note: All BSV, WSV and RV are expressed as CV (%).
BSV=Between-subject variability, WSV=Within-subject variability, RV=Residual variability, MTT=mean transit time, NN=number of transit compartments, ka=absorption rate constant