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. 2014 Mar 3;8:66. doi: 10.3389/fncel.2014.00066

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Copyright © 2014 Poon, Goh, Voorhoeve and Fivaz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluating the variability of presynaptic induction using software-based analysis of synaptic vesicle (SV) clusters induced by LRRTM2. (A) Raw confocal images (20×) of GFP-expressing neurons cultured with HEK293T cells transfected with mCherry alone (top row) or mCherry and LRRTM2 (bottom row) and immunostained against synaptobrevin. The overlap region map and corresponding SV clusters (black) is displayed on the right. Scale bar, 20 μm. (B) Mean percentage of axon-HEK293T overlap regions containing SV clusters (SV cluster frequency) from six different fields, across three independent experiments. HEK293T cells express mCherry (control) or mCherry together with LRRTM2. p < 0.001, ANOVA. No significant difference (p = 0.78) between the three independent neuronal preparations. (C) Fraction of area of overlap region occupied by SV clusters (SV cluster density). p < 0.05, ANOVA. No significant difference (p = 0.44) between the three independent neuronal preparations.