Table 1.
Baseline demographic and comorbidity characteristics of study cohort from January 1999 to July 2009
| Variables |
ADPKD |
Non-ADPKD |
P-value |
|---|---|---|---|
| (n = 6,749) | (n = 506,023) | ||
| Gender |
|
|
0.426 |
| Male |
3,551 (52.6) |
268,709 (53.1) |
|
| Female |
3,198 (47.4) |
237,314 (46.9) |
|
| Race |
|
|
<0.001 |
| AA |
848 (12.6) |
123,256 (24.4) |
|
| Non-AA |
5,901 (87.4) |
382,767 (75.6) |
|
| Mean age at start of dialysis (yr) |
65.30 |
70.20 |
< 0.001 |
| (95% CI 65.01-65.64) |
(95% CI 70.21-70.28) |
||
| Dialysis modality |
|
|
<0.001 |
| Hemodialysis |
4,636 (79.4) |
412,185 (92.4) |
|
| Peritoneal dialysis |
1,206 (20.6) |
34,163 (7.7) |
|
| Receipt of kidney transplant |
1,784 (26.4) |
24,743 (4.9) |
<0.001 |
| CHF |
1,002 (14.9) |
197,017 (39.6) |
<0.001 |
| Atherosclerotic heart disease |
1,144 (17.0) |
152,623 (30.7) |
<0.001 |
| Cerebrovascular disease (CVA, TIA) |
541 (8.0) |
59,859 (12.0) |
<0.001 |
| Peripheral vascular disease |
452 (6.7) |
91,337 (18.4) |
<0.001 |
| Hypertension |
5,682 (84.4) |
405,168 (81.4) |
<0.001 |
| Diabetes mellitus |
480 (7.1) |
212,998 (42.8) |
<0.001 |
| COPD |
470 (7.0) |
55,199 (11.1) |
<0.001 |
| Tobacco use |
426 (6.3) |
23,207 (4.7) |
<0.001 |
| Alcohol dependence |
43 (0.6) |
4,862 (1.0) |
0.005 |
| Mean hemoglobin (g/dL) |
10.81 |
10.16 |
<0.001 |
| (95% CI 10.75-10.87) |
(95% CI 10.16-10.17) |
||
| Mean serum albumin (g/dL) |
3.66 |
3.13 |
<0.001 |
| (95% CI 3.63-3.69) |
(95% CI 3.13-3.14) |
||
| Mean total cholesterol (mg/dL) |
159.50 |
151.16 |
<0.001 |
| (95% CI 155.86-163.14) |
(95% CI 150.68-151.64) |
||
| Mean low density lipoprotein (mg/dL) |
92.61 |
87.41 |
0.017 |
| (95% CI 88.39-96.83) |
(95% CI 86.85-87.96) |
||
| Mean body mass index (kg/m2) | 27.10 |
28.34 |
<0.001 |
| (95% CI 26.83-27.37) | (95% CI 28.30-28.37) |
Data are n (%) or mean ± standard deviation.
Univariate analyses were performed with Chi-square testing for categorical variables (Fisher’s exact test used for violations of Cochran’s assumptions) and Student's t-test for continuous variables (Mann–Whitney test used for non-normally distributed variables).
ADPKD: autosomal dominant polycystic kidney disease; AA: African American; COPD: chronic obstructive pulmonary disease; CHF: congestive heart failure; CVA: cerebrovascular accident; TIA: transient ischemic attack.