Fig. 1.

Voxel-based regression analysis between the C/cv[¹¹C]PiB uptake ratio and the frequency of LRP-1T alleles, controlled for copies of the ApoE ε4 allele and sex. Significant (p < 0.05, corrected for multiple comparisons using family wise error) correlations are depicted in yellow and are projected on axial T1-MRI scans (average of 152 scans, implemented in SPM8), numbers indicate z-coordinates of slices in Talairach space in mm. LRP-1 T allele: Low Density Lipoprotein receptor-related protein C667T polymorphism; [¹¹C]PiB: Pittsburgh compound B.