Fig. 3.

Scatterplots of sub-group regression analysis after stratifying patients into ApoE ε4 carriers and non-carriers using the C/cv[¹¹C]PiB uptake as dependent variable, the LRP-1 T allele frequency as independent variable controlling for gender. A) in ApoE ε4 carriers: significant model (p = 0.018); adjusted R² = 0.141, standardized coefficient ß for LRP-T allele frequency = 0.378 (p = 0.013). B) in ApoE ε4 non-carriers: not significant (p = 0.794). ApoE: apolipoprotein E; LRP-1 T allele: Low Density Lipoprotein receptor-related protein C667T polymorphism; [¹¹C]PiB: Pittsburgh compound B.