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. Author manuscript; available in PMC: 2014 Mar 3.
Published in final edited form as: Curr Pharm Des. 2011 Nov;17(33):3729–3740. doi: 10.2174/138161211798220918

Fig. (2).

Fig. (2)

Confocal imaging showing the coexistence of MC4R and ObR in the median eminence of the mouse hypothalamus. MC4R (red) expression exhibited intense fiber-like staining and intermittent diffuse signaling in both wildtype (A) and ob/ob (D) mice. ObR (green) expression in wildtype mice (B) showed fiber and membrane-localized punctate staining, whereas ObR staining in ob/ob mice was more intense (E). The merged picture of MC4R and ObR staining shows the coexistence of both receptors in neuron-like cells (arrows) in the median eminence of both wildtype (C) and ob/ob mice (F). Scale bar: 10 μm.