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. Author manuscript; available in PMC: 2014 Mar 3.
Published in final edited form as: Curr Pharm Des. 2011 Nov;17(33):3729–3740. doi: 10.2174/138161211798220918

Fig. (3).

Fig. (3)

Effect of cytokines on ABCA-1 transporter promoter activity in RBE4 cells transfected with ABCA-1 luciferase promoter and control Renilla luciferase plasmids. Basal activity was significantly reduced when the cells were treated with TNF (5ng/ml), IL-15 (5ng/ml), or leptin 0.8μg/ml for 6 h (empty bars). Co-treatment of the cells with LXR ligand T0901317 (T09; 1 μM) and RXR ligand 9-cis retinoic acid (9cRA; 100 nM) induced a small but significant increase of ABCA-1 promoter activity in the phosphate-buffered saline (PBS) control group. Cytokine treatment did not affect this activation pattern (solid bars). ***: p < 0.005 in comparison with vehicle treatment (n = 3 /group).