Table 2.
Demographic and MRI volumetric summaries for Cardiovascular Health Study and Healthy Brain Project participants.
| Cardiovascular health study | Healthy brain project | p-value | |
|---|---|---|---|
| Sample size | n = 286 | n = 302 | |
| Female (n, %) | 177 (62%) | 174 (58%) | 0.33 |
| White (n, %) | 224 (78%) | 181 (60%) | <0.001a |
| Obese (n, %) | 46 (16%) | 79 (26%) | 0.004a |
| Age [mean (SD)] | 78 (4.0) | 83 (2.8) | <0.001a |
| 3MS score [mean (SD)] | 93.6 (5.2) | 92.9 (6.7) | 0.92 |
| MRI volumes [mean mm3 (SD)]b | |||
| Amygdala | 2786 (605) | 2934 (419) | |
| Anterior cingulate cortex | 10554 (1587) | 9615 (1517) | |
| Caudate | 7704 (1835) | 8586 (2047) | |
| Cerebellum | 68220 (24799) | 99264 (12788) | |
| Dorsolateral prefrontal cortex | 67790 (9706) | 26837 (3240) | |
| Entorhinal cortex | 3922 (808) | 3702 (664) | |
| Hippocampus | 9649 (1296) | 9452 (1205) | |
| Lateral parietal inferior cortex | 10368 (2061) | 10990 (1527) | |
| Lateral parietal superior cortex | 9719 (2342) | 11787 (1807) | |
| Medial parietal cortex | 18483 (3408) | 20611 (3031) | |
| Pallidum (natural logarithm) | 5.49 (1.11) | 5.90 (0.93) | |
| Parahippocampus | 10144 (1570) | 10663 (1608) | |
| Parenchyma (total gray matter) | 466482 (66738) | 527997 (55062) | |
| Post-central gyrus | 15255 (3132) | 18972 (2730) | |
| Posterior cingulate cortex | 2557 (458) | 2816 (695) | |
| Pre-central gyrus | 13485 (2579) | 16741 (2538) | |
| Putamen | 2192 (1946) | 3002 (2443) | |
| Supplementary motor cortex | 9260 (2168) | 128218 (2220) | |
| Thalamus | 1872 (1016) | 1856 (460) | |
a
Significant with α = 0.05.
b
Mean volumes are expected to differ since the CHS and HBP used different MR scanners, thus p-values are not reported.