Table 3.

NFKB1 genetic polymorphisms with the risk of primary liver cancer

SNPs	Cases	Controls	p Value for χ2	OR*	95% CI	OR†	95% CI	OR‡	95% CI
rs28362491
ins/ins	68	171	–	1.00	–	1.00	–	1.00	–
ins/del	102	160	–	1.60	1.10 to 2.33	1.60	1.10 to 2.33	1.71	1.13 to 2.60
del/del	40	79	0.047	1.27	0.79 to 2.05	1.27	0.79 to 2.04	1.21	0.71 to 2.05
p value for trend	–	–	–	0.144	–	0.146	–	0.233	–
ins/del or del/del	142	239	0.023	1.50	1.05 to 2.12	1.49	1.05 to 2.12	1.54	1.04 to 2.28
rs230496
AA	64	164	–	1.00	–	1.00	–	1.00	–
AG	101	169	–	1.53	1.05 to 2.24	1.53	1.05 to 2.24	1.68	1.10 to 2.58
GG	47	91	0.087	1.33	0.84 to 2.09	1.32	0.84 to 2.09	1.25	0.75 to 2.09
p value for trend	–	–	–	0.141	–	0.143	–	0.235	–
AG or GG	148	260	0.041	1.46	1.03 to 2.08	1.46	1.03 to 2.08	1.53	1.03 to 2.26
rs230525
AA	79	186	–	1.00	–	1.00	–	1.00	–
AG	102	175	–	1.38	0.96 to 1.97	1.38	0.96 to 1.98	1.46	0.98 to 2.18
GG	32	63	0.224	1.20	0.73 to 1.98	1.20	0.73 to 1.97	1.11	0.63 to 1.94
p value for trend	–	–	–	0.236	–	0.236	–	0.347	–
AG or GG	134	238	0.100	1.33	0.95 to 1.87	1.33	0.95 to 1.87	1.36	0.94 to 1.99
rs230530
AA	64	114	–	1.00	–	1.00	–	1.00	–
AG	99	175	–	1.01	0.68 to 1.49	1.01	0.68 to 1.49	1.05	0.68 to 1.62
GG	48	129	0.102	0.66	0.42 to 1.04	0.66	0.42 to 1.04	0.67	0.40 to 1.12
p value for trend	–	–	–	0.079	–	0.078	–	0.132	–
AG or GG	147	304	0.423	0.86	0.60 to 1.24	0.86	0.60 to 1.24	0.89	0.59 to 1.34

*Adjusted for age.

†Adjusted for age and sex.

‡Adjusted for age, sex, education level, family history of liver cancer, history of hepatitis and chronic liver diseases or cirrhosis.

SNP, single-nucleotide polymorphism.