Table 4.

NFKBIA genetic polymorphisms with the risk of primary liver cancer

SNPs	Cases	Controls	p Value	OR*	95% CI	OR†	95% CI	OR‡	95% CI
rs3138053
AA	173	336	–	1.00	–	1.00	–	1.00	–
AG	21	48	–	0.85	0.49 to 1.47	0.84	0.48 to 1.45	0.97	0.54 to 1.74
GG	19	40	0.823	0.92	0.52 to 1.64	0.94	0.52 to 1.68	0.98	0.51 to 1.88
p value for trend	–	–	–	0.638	–	0.653	–	0.920	–
AG or GG	40	88	0.556	0.88	0.58 to 1.34	0.88	0.58 to 1.34	0.97	0.61 to 1.54
rs3138055
CC	62	128	–	1.00	–	1.00	–	1.00	–
CT	109	215	–	1.05	0.72 to 1.54	1.05	0.72 to 1.54	1.22	0.79 to 1.87
TT	42	81	0.956	1.07	0.66 to 1.73	1.07	0.66 to 1.73	1.33	0.78 to 2.27
p value for trend	–	–	–	0.772	–	0.771	–	0.276	–
CT or TT	151	296	0.778	1.06	0.74 to 1.51	1.06	0.74 to 1.52	1.25	0.83 to 1.88
rs696
CC	65	149	–	1.00	–	1.00	–	1.00	–
CT	115	196	–	1.35	0.93 to 1.96	1.35	0.93 to 1.96	1.47	0.97 to 2.23
TT	33	76	0.210	0.99	0.60 to 1.64	0.99	0.60 to 1.64	1.17	0.67 to 2.03
p value for trend	–	–	–	0.694	–	0.695	–	0.360	–
CT or TT	148	272	0.218	1.25	0.88 to 1.78	1.25	0.88 to 1.78	1.38	0.93 to 2.06
rs2273650
CC	108	215	–	1.00	–	1.00	–	1.00	–
CT	84	173	–	0.97	0.68 to 1.37	0.97	0.68 to 1.37	0.86	0.58 to 1.26
TT	20	37	0.938	1.08	0.60 to 1.95	1.07	0.59 to 1.94	0.89	0.45 to 1.73
p value for trend	–	–	–	0.937	–	0.945	–	0.493	–
CT or TT	104	210	0.933	0.99	0.71 to 1.38	0.99	0.71 to 1.37	0.86	0.60 to 1.24

*Adjusted for age.

†Adjusted for age and sex.

‡Adjusted for age, sex, education level, family history of liver cancer, history of hepatitis and chronic liver diseases or cirrhosis.

SNP, single-nucleotide polymorphism.