Table 1.

Genotype interaction analysis of PARK2 SNPs with proinflammatory /anti-inflammatory cytokines gene SNPs providing risk/protection towards leprosy susceptibility

PARK2 (SNPs are within 63.8 kb upstream gene region)						Samples (n)				95% CI for EXP(B)
		Gene	SNPs providing risk			Patients	Controls	Significance	OR	Lower	Upper
rs9365492; minor, risk allele-C	rs9355403; minor, risk allele-A	IL-10	rs1800871 (−819); minor, risk allele-T	rs1554286 (intron 3 boundary); minor, risk allele-T	rs1800872 (−592); minor, risk allele-A
TC+CC	GA+AA		CT+TT	TT	CA+AA	82	84	3.22E-05	1.997	1.441	2.767
		TGFBR2	rs2228048 (3' UTR downstream); minor, risk allele-T	rs744751 (3′ UTR downstream); minor, risk allele-G
			CT+CC	GG		287	400	1.04E-02	1.293	1.062	1.575
		IL-6	rs1800797 (−718); minor, risk allele-G
			GG			320	432	2.90E-03	1.333	1.103	1.611
		TNF	rs1800629 (−308); minor, risk allele-G	rs1800610 (Intron-1); minor, risk allele-G
			GG	GG		311	420	2.06E-09	2.103	1.649	2.682
		BTNL2-DRA interval	rs3135365; minor, risk allele-C	rs7773756; minor, risk allele-T
			CA+CC	CT+TT		272	269	1.22E-21	5.4	3.821	7.631
			SNPs providing protection
TT	GG	LTA	rs13192469 (13 kb upstream); minor, risk allele-C	rs36221459 (−1409); minor, risk allele-DEL
			TT	GTTT		240	571	3.56E-07	0.616	0.512	0.743
		IL-10RB2	rs3171425 (3’ UTR); major, risk allele-G	rs7281762 (3′ UTR downstream); minor, risk allele-A
			GA+AA	GA+GG		164	391	1.10E-05	0.61	0.489	0.76
		BAT1	rs2523504 (−603); minor, risk allele-T
			CC			192	475	4.15E-05	0.645	0.523	0.795
		NFKBIL	rs2230365 (exon-3); minor, risk allele-T
			CC			195	486	1.01E-07	0.589	0.484	0.715
		TNF-LTB	rs769178 (gene downstream); major, risk allele-G
			GT+TT			66	211	8.93E-05	0.546	0.404	0.739
		IL12B	rs2853694; major, risk allele-A
			CA+CC			233	519	5.03E-04	0.705	0.579	0.858

IL, interleukin; SNP, single-nucleotide polymorphism; TNF, tumour necrosis factor.