Table 3.
Univariate Analysis of Factors Associated With 3-Year Death/HTx/VAD Requirement
| All Patients (N = 260) |
Patients off Anticoagulation (n = 156) |
Patients on Anticoagulation (n = 104) |
||||
|---|---|---|---|---|---|---|
| Variable | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value |
| MELD | 1.10 (1.06–1.14) | <0.0001 | 1.19 (1.10–1.29) | <0.0001 | 1.06 (0.99–1.13) | 0.0816 |
| MELDNa | 1.10 (1.06–1.14) | <0.0001 | 1.20 (1.11–1.30) | <0.0001 | 1.06 (1.00–1.13) | 0.0620 |
| MELD-XI | 1.13 (1.07–1.19) | <0.0001 | 1.14 (1.05–1.22) | 0.0020 | 1.13 (1.03–1.23) | 0.0098 |
| Age | 1.01 (0.99–1.03) | 0.4751 | 1.00 (0.98–1.03) | 0.7488 | 1.01 (0.98–1.04) | 0.6499 |
| Male | 0.89 (0.51–1.63) | 0.6936 | 0.98 (0.43–2.53) | 0.9717 | 0.76 (0.36–1.74) | 0.4926 |
| BMI | 0.93 (0.88–0.97) | 0.0030 | 0.94 (0.87–1.00) | 0.0688 | 0.89 (0.81–0.96) | 0.0046 |
| Diabetes | 1.44 (0.78–2.52) | 0.2304 | 2.26 (0.95–5.02) | 0.0634 | 0.95 (0.38–2.11) | 0.9142 |
| Heart rate | 0.99 (0.97–1.01) | 0.4903 | 1.00 (0.97–1.02) | 0.9042 | 0.99 (0.97–1.02) | 0.5401 |
| Mean arterial BP | 0.95 (0.93–0.97) | <0.0001 | 0.95 (0.91–0.98) | 0.0006 | 0.95 (0.92–0.98) | 0.0006 |
| Atrial fibrillation | 1.49 (0.81–2.68) | 0.1942 | 1.39 (0.40–3.67) | 0.5630 | 0.91 (0.40–2.14) | 0.8240 |
| Laboratory examination | ||||||
| WBC | 0.94 (0.82–1.08) | 0.4203 | 0.98 (0.80–1.19) | 0.8597 | 0.88 (0.71–1.08) | 0.2306 |
| Hemoglobin | 0.69 (0.60–0.81) | <0.0001 | 0.59 (0.48–0.74) | <0.0001 | 0.80 (0.63–1.00) | 0.0482 |
| Platelets | 1.00 (1.00–1.00) | 0.8401 | 1.00 (1.00–1.01) | 0.4890 | 1.00 (0.99–1.01) | 0.8764 |
| Serum sodium | 0.87 (0.80–0.96) | 0.0062 | 0.85 (0.72–1.02) | 0.0758 | 0.91 (0.82–1.02) | 0.1081 |
| BUN | 1.03 (1.01–1.04) | <0.0001 | 1.02 (1.00–1.04) | 0.0189 | 1.05 (1.03–1.07) | <0.0001 |
| Creatinine | 1.09 (0.89–1.22) | 0.3506 | 1.04 (0.73–1.22) | 0.7521 | 1.83 (1.15–2.62) | 0.0155 |
| Total bilirubin | 1.24 (1.03–1.43) | 0.0237 | 1.25 (0.94–1.53) | 0.1113 | 1.21 (0.92–1.46) | 0.1487 |
| AST | 1.01 (0.99–1.03) | 0.2662 | 1.02 (0.99–1.06) | 0.1202 | 1.00 (0.97–1.02) | 0.9332 |
| ALT | 1.00 (0.98–1.02) | 0.9180 | 0.99 (0.96–1.01) | 0.3889 | 1.01 (0.98–1.02) | 0.4987 |
| Albumin | 0.91 (0.45–1.91) | 0.8082 | 0.53 (0.19–1.55) | 0.2443 | 1.74 (0.62–5.23) | 0.3004 |
| INR | 1.48 (1.13–1.88) | 0.0060 | 2.13 (0.91–3.97) | 0.0766 | 1.21 (0.80–1.74) | 0.3452 |
| Total cholesterol | 0.99 (0.98–0.99) | <0.0001 | 0.98 (0.98–0.99) | 0.0002 | 0.99 (0.98–1.00) | 0.0150 |
| BNP | 1.00 (1.00–1.00) | <0.0001 | 1.00 (1.00–1.00) | <0.0001 | 1.00 (1.00–1.00) | 0.0576 |
| Peak VO2 | 0.84 (0.78–0.90) | <0.0001 | 0.79 (0.70–0.88) | <0.0001 | 0.90 (0.81–0.99) | 0.0327 |