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Schematic overview of PIK3CA related cell signaling pathways in colorectal cancer. AA, arachidonic acid; AKT, protein kinase B; ERK, extracellular signal-regulated kinase, MEK, MAP kinase kinase; mTOR, mammalian target of rapamycin; PTEN, phosphatase and tensin homolog deleted on chromosome 10; PGG2, prostaglandin G2; PGH2, prostaglandin H2; PI3K, phosphatidylinositol-3-kinase; RAF, rapidly accelerated fibrosarcoma; RAS, rat sarcoma; RTK, receptor tyrosine kinase.
