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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2013 Dec 15;274(3):417–424. doi: 10.1016/j.taap.2013.12.003

Figure 6. Allopurinol pretreatment induces metallothionein.

Figure 6

Mice were given water, allopurinol for 18h or allopurinol for 1h by oral gavage and fasted overnight to mimic the previously described allopurinol pretreatments. The 18h pretreatment causes the mRNA induction of metallothionein-1 (Mt-1) and metallothionein-2 (Mt-2) genes (A). Confirming the mRNA data, metallothionein protein was increased by the 18h pretreatment as determined by western blotting and compared to β-actin (B). Data are expressed as means ± SE, n=3 mice per group. *P<0.05 (compared to control).