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. Author manuscript; available in PMC: 2014 Mar 3.
Published in final edited form as: Lancet Neurol. 2012 Dec 21;12(2):139–148. doi: 10.1016/S1474-4422(12)70311-3

Table 3.

Change in use of alteplase

Pre-intervention phase (24 months) Intervention phase (12 months) Post-intervention phase (25 months) Relative risk (95% CI)* p value
Intention-to-treat analysis
Control hospitals 99/7946 (1.25%) 61/4212 (1.45%) 194/9222 (2.10%) ..
Intervention hospitals 89/7119 (1.25%) 67/3905 (1.72%) 235/8419 (2.79%) 1.37 (0.96–1.93) 0.08
Target-population analysis
Control hospitals 65/5957 (1.09%) 40/3082 (1.30%) 120/6989 (1.72%) ..
Intervention hospitals 59/5882 (1.00%) 53/3339 (1.59%) 191/7288 (2.62%) 1.68 (1.09–2.57) 0.02

Data are number of patients in the emergency department treated with alteplase/number of patients discharged after a diagnosis of acute stroke (%) unless otherwise stated.

*

Relative risk compares the change between pre-intervention and post-intervention phases in intervention hospitals with the change in control hospitals.