Table 1.
Bone mineral density and bone measurements in chronically sleep-restricted and ambulation control rats.
Bone Indicesa | Ambulation Control |
Chronic Sleep Restriction |
P Value* | |
---|---|---|---|---|
Osteoid thickness† | 4.0 ± 1.6 | 0.6 ± 1.1 | 0.0001* | |
Bone Mineral Density (g/cm2) | 0.213 ± 0.009 | 0.189 ± 0.010 | 0.0004* | |
Osteoid (% bone perimeter)† | 21.4 ± 15.1 | 0.5 ± 0.8 | 0.002* | |
Osteoblasts (number)† | 28.3 ± 18.4 | 0.4 ± 0.8 | 0.001* | |
Osteoblast activity (µm3)† | 1033 ± 766 | 11 ± 23 | 0.002* | |
Growth plate thickness (µm) | 130 ± 9 | 114 ± 15 | 0.055 | |
Perimeter of metaphyseal bone (µm) | 10594 ± 4248 | 7069 ± 3702 | 0.091 | |
Tibia length (mm) | 44.5 ± 0.7 | 43.8 ± 0.4 | 0.159 | |
Cortical bone thickness (µm) | ||||
Near growth plate | 339 ± 72 | 308 ± 38 | 0.354 | |
In the diaphysis | 391 ± 35 | 358 ± 62 | 0.280 | |
Resorption surface (osteoclasts;% of bone perimeter) | 6.4 ± 5.6 | 9.8 ± 7.8 | 0.317 |
Values are means ± standard deviation.
N = 6–10 rats per group after unsatisfactory specimens were excluded, except for tibia length for which N = 3–5.
Statistical significance after Holm’s correction for multiple comparisons.
Includes zero values.