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. Author manuscript; available in PMC: 2014 Mar 3.
Published in final edited form as: Exp Biol Med (Maywood). 2012 Sep 3;237(9):1101–1109. doi: 10.1258/ebm.2012.012043

Table 1.

Bone mineral density and bone measurements in chronically sleep-restricted and ambulation control rats.

Bone Indicesa Ambulation
Control
Chronic Sleep
Restriction
P Value*

Osteoid thickness 4.0 ± 1.6 0.6 ± 1.1 0.0001*

Bone Mineral Density (g/cm2) 0.213 ± 0.009 0.189 ± 0.010 0.0004*

Osteoid (% bone perimeter) 21.4 ± 15.1 0.5 ± 0.8 0.002*

Osteoblasts (number) 28.3 ± 18.4 0.4 ± 0.8 0.001*

Osteoblast activity (µm3) 1033 ± 766 11 ± 23 0.002*

Growth plate thickness (µm) 130 ± 9 114 ± 15 0.055

Perimeter of metaphyseal bone (µm) 10594 ± 4248 7069 ± 3702 0.091

Tibia length (mm) 44.5 ± 0.7 43.8 ± 0.4 0.159

Cortical bone thickness (µm)
Near growth plate 339 ± 72 308 ± 38 0.354
In the diaphysis 391 ± 35 358 ± 62 0.280

Resorption surface (osteoclasts;% of bone perimeter) 6.4 ± 5.6 9.8 ± 7.8 0.317

Values are means ± standard deviation.

a

N = 6–10 rats per group after unsatisfactory specimens were excluded, except for tibia length for which N = 3–5.

*

Statistical significance after Holm’s correction for multiple comparisons.

Includes zero values.

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