Table 2.

Adjusted Hazard Ratios for Incident Diabetes According to Baseline Uric Acid Concentration, Atherosclerosis Risk in Communities Study, 1987–1998

Visit-based Diabetes (During 9 Years of Follow-up) (n =11,134)	No. of Cases	Risk of Incident Diabetes
		Model 1a		Model 2b		Model 3c
		HR	95% CI	HR	95% CI	HR	95% CI
Quartile of uric acid concentration, mg/dL
≤4.9	165	1	Reference	1	Reference	1	Reference
5.0–5.8	218	1.54	1.25, 1.88	1.10	0.89, 1.35	0.91	0.74, 1.12
5.9–6.9	397	2.77	2.29, 3.35	1.51	1.24, 1.84	1.20	0.98, 1.46
7.0–15.9	514	4.33	3.58, 5.24	1.79	1.45, 2.21	1.12	0.90, 1.39
P-trendd		<0.001		<0.001			0.11
Uric acid concentration, per 1 mg/dL	1,294	1.39	1.34, 1.44	1.18	1.13, 1.23	1.05	1.00, 1.10
P value		<0.001		<0.001		0.03

Abbreviations: CI, confidence interval; HR, hazard ratio.

^a Results were adjusted for age, sex, and race/study center.

^b Results were adjusted for all variables in model 1 plus low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, body mass index, estimated glomerular filtration rate, hypertension, parental family history of diabetes, education, smoking status, alcohol use, and diuretic use.

^c Results were adjusted for all variables in model 2 plus fasting glucose and fasting insulin levels.

^d P-trend was calculated using the median value of each quartile to construct an ordinal variable.