Table 3.

Cross-Sectional Association Between Diabetes Duration and Visit 4 Uric Acid Concentration (mg/dL) or 9-year Within-Person Change in Uric Acid Concentration (n =1,510^a), Atherosclerosis Risk in Communities Study, 1987–1998

	Model 1b		Model 2c		Model 3d
	β	95% CI	β	95% CI	β	95% CI
Mean uric acid concentration
Category of diabetes duration, years
0.0–4.3 (n = 378)	1	Reference	1	Reference	1	Reference
4.4–7.2 (n = 377)	−0.29	−0.50, −0.08	−0.15	−0.34, 0.03	−0.09	−0.27, 0.10
7.3–9.0 (n = 467)	−0.55	−0.75, −0.35	−0.36	−0.54, −0.18	−0.16	−0.34, 0.02
9.1–65.0 (n = 288)	−0.52	−0.75, −0.30	−0.49	−0.69, −0.29	−0.27	−0.47, −0.06
P-trende		<0.001		<0.001		0.01
Continuous diabetes duration   (per 5 years)	−0.15	−0.21, −0.09	−0.15	−0.20, −0.09	−0.10	−0.15, −0.04
Mean 9-year within-person change in    uric acid concentration
Category of diabetes duration, years
0.0–4.3 (n = 378)	1	Reference	1	Reference	1	Reference
4.4–7.2 (n = 377)	−0.42	−0.63, −0.21	−0.37	−0.58, −0.17	−0.32	−0.52, −0.11
7.3–9.0 (n = 467)	−0.68	−0.88, −0.48	−0.61	−0.81, −0.41	−0.42	−0.62, −0.22
9.1–65.0 (n = 288)	−0.04	−0.27, 0.19	−0.06	−0.28, 0.17	0.16	−0.08, 0.39
P-trende		0.32		0.27		0.30
Mean 9-year change (per 5 years   with diabetes)	−0.01	−0.08, 0.05	−0.03	−0.09, 0.03	0.02	−0.04, 0.08

Abbreviation: CI, confidence interval.

^a This analysis was conducted among visit 4 participants who had a visit-based diagnosis of diabetes by visit 4.

^b Results were adjusted for age, sex, and race/study center.

^c Results were adjusted for model 1 variables plus low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, body mass index, estimated glomerular filtration rate, hypertension, parental family history of diabetes, education, smoking status, alcohol use, and diuretic use.

^d Results were adjusted for model 2 variables plus fasting glucose and fasting insulin levels.

^e P-trend was calculated using the median value of each quartile to construct an ordinal variable.