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. 2014 Feb 10;111(8):3158–3163. doi: 10.1073/pnas.1318954111

Fig. 1.

Fig. 1.

Effect of ADCYAP1R1 genotype on regional activation. (A) Increased activation within the amygdala ROI for the risk (CC, n = 22) relative to nonrisk (GC, GG, n = 27) group (left amygdala: Z = 2.59, k = 52, x, y, z = −20, −4, −12; right amygdala: Z = 2.53, k = 30, x, y, z = 24, 0, −12). (B) Increased activation within the hippocampus ROI for risk relative to nonrisk group (left hippocampus: Z = 3.18, k = 103, x, y, z = −16, −36, −8; right hippocampus: Z = 2.57, k = 67, x, y, z = 8, −36, −4). Significant clusters (pcorr < 0.05) are overlaid on slices from a representative ICBM 152 template brain. Slices are displayed in neurological orientation. Red–yellow color scale indicates increased activation for the risk group relative to the nonrisk group. Bar charts show the mean of contrast values across all voxels in the anatomical ROIs, for the fearful > neutral contrast. Error bars represent ±1 SEM.