Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 3;111(8):3176–3181. doi: 10.1073/pnas.1322657111

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 4. — The effect of TRPM2 knockdown on hepatocyte membrane currents and Ca²⁺ entry. (A) The effect of TRPM2 knockdown on the amplitude of membrane currents activated by intracellular ADPR, H₂O₂, and acetaminophen. The absolute amplitude of the current measured at −100 mV is shown (mean ± SEM). (B) Western blot of TRPM2 protein in hepatocytes treated with control siRNA (lane 2) and anti-TRPM2 siRNA (lane 3). (C) The effect of TRPM2 knockdown on Ca²⁺ entry in rat hepatocytes preincubated with 0.5 mM H₂O₂ for 30 min. (D) The effect of TRPM2 knockdown on Ca²⁺ entry in rat hepatocytes preincubated with 10 mM acetaminophen for 60 min.