Fig. 5.

H₂O₂- and acetaminophen-activated Ca²⁺ entry is attenuated in TRPM2 KO mouse hepatocytes. (A and B) Ca²⁺ entry in TRPM2 WT (A) and KO (B) mouse hepatocytes activated by the addition of H₂O₂ to the bath solution (n = 3). (C) Ca²⁺ entry in TRPM2 WT and KO mice hepatocytes treated with 10 mM acetaminophen for 60 min (n = 3). Both clotrimazole (50 μM) and ACA (10 μM) were applied to the bath 5 min before the addition of Ca²⁺.