Fig. 6.

TRPM2 KO mice are substantially protected against acetaminophen-induced damage. (A) Blood concentrations of the liver enzymes ALT and AST in TRPM2 KO, TRPM2 Het, and WT mice pretreated with acetaminophen or vehicle for 24 h. The results are the means ± SEM of the number of mice indicated. The degree of significance, determined using the one way ANOVA test was P < 0.007 for comparison of TRPM2 KO with each of TRPM2 WT and TRPM2 Het. (B) Representative bright field images of H&E-stained liver sections at 20× magnification. The light colored areas in the WT acetaminophen and KO acetaminophen images represent areas of necrosis.