Fig. 2.

Using the semantic similarity-integrated approach for modularization approach, 713 DEGs associated with stress-induced heart injury were grouped into functional modules. (A) The mean fold change profiles of the modules are depicted by a heat map, and the biological processes associated with each module are listed next to each heat map. NK, natural killer. We also constructed hypothetical regulatory networks for three selected modules regulated by (B and C) TFs and (D) miRNA. Expression-level changes of individual genes across different experimental conditions are expressed in concentric circles, where the innermost circles represent the fold changes between stressed and control samples in the shortest exposure group (T1R1) and the outermost circles represent the longest exposure group (T10R1).